Visual Abstract - Serial Coronary Imaging of Early Atherosclerosis Development in Fast-Food-Fed Diabetic and Nondiabetic Swine: 10.1016/j.jacbts.2016.08.006

In swine with and without diabetes mellitus fed a fast-food diet:

• OCT, NIRS, CCTA, vascular function testing, and histology can be consecutively and longitudinally performed to assess gradual coronary atherosclerosis development

• OCT and NIRS enabled detailed assessment of early coronary atherosclerosis development, whereas CCTA was not able to detect discrete early atherosclerotic changes.

• OCT, NIRS, vascular function testing, and histology demonstrated no differences in early atherosclerosis development.