Figure 8: PP2Ce Expression Impairs ISO Stimulated Enhancement of Contractility

(A) Representative left ventricle pressure (LVP) measured from isolated hearts of wildtype or PP2Ce TG mice at basal or perfused by 1 μmol/l of ISO. (B) Hemodynamic parameters from control (n = 9) and PP2Ce TG (n = 6) hearts at basal or treated by 10 nmol/l ISO. *p < 0.05; **p < 0.01 between basal and I/R within control or PP2Ce TG groups. #p < 0.05 between corresponding control and PP2Ce TG. dP/dt max = maximal systolic pressure derivative; dP/dt min = maximal diastolic pressure derivative; HR = heart rate; I/R = ischemia/reperfusion; LVDP = left ventricle developed pressure (Pmax − Pmin); Pmax = systolic pressure; Pmin = diastolic pressure; Tau = relaxation index; other abbreviations as in Figures 2, 3, and 4.



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