Figure 7: RBX Reduces EDPVR and Improves Contractility

Serial invasive hemodynamics were performed at baseline (B), 3 months PMI ± DOB, and ± RBX. (A) Representative pressure-volume loops at 3 months after MI + DOB or + RBX. (B) EDPVR was not altered ± DOB, but shifted leftward with RBX. (C) ESPVR was not significantly altered 3 months PMI + DOB but was also shifted leftward with RBX. (D) PRSW was increased at both time points but to a greater extend with RBX. (E) LVVPed10 was significantly reduced in the presence of RBX at 3 months PMI versus 3 months PMI +DOB. (F) The LVVPes80 was significantly reduced at 3 months PMI +RBX, but not ± DOB. (G) EF was increased significantly by DOB and RBX at 3 months PMI, but due to profound reductions in the EDV with RBX. (H) The Ees, 1 of 2 determinants of the ESPVR, was significantly increased at +RBX versus 3 months PMI. (I) The volume intercept, second determinant of the ESPVR, was significantly changed at 3 months PMI + RBX vs. ± DOB. RBX (yellow bars = 2.5 μg/kg/min RBX. *p ≤ 0.05, **p ≤ 0.005 versus baseline; †p ≤ 0.05, ††††p ≤ 0.0005 versus 3 months PMI; ‡p ≤ 0.05, ‡‡‡p ≤ 0.001, ‡‡‡‡p ≤ 0.0005 versus 3 months PMI + DOB. Abbreviations as in Figures 1, 2, and 4.