Figure 7: Microvascular Density and Cardioproliferation Enhanced by CDCs, While Fibroblast Proliferation Is Suppressed

(A) Immunostaining for von Willebrand factor (VWF) and smooth muscle actin (SMA) in control, placebo-treated, and cardiosphere-derived cell (CDC)–treated rats. CDC treatment increases arteriolar (B) and capillary (C) density in the left ventricle. (D) Immunostaining for Ki67 and α-actinin (SA) and for Ki67 and vimentin in control, placebo-treated, and CDC-treated rats. CDC treatment increased cardiomyocyte (CM) proliferation (E) and decreased the proliferation of fibroblasts (F) compared with placebo. n = 5 in each group. †p < 0.05 versus control and CDC-treated rats, both by analysis of variance; ‡p < 0.05 versus control and placebo-treated rats. DAPI = 4′,6-diamidino-2-phenylindole.