Figure 7: Histological-Derived |HAT|

(A) Single representative case, (B) group comparison, and (C) correlation and agreement with DT-CMR–derived |HAT| values. The stained hematoxylin and eosin histological sections clearly show the orientation of the myocardial fibers at varying transmural depths, which can be quantified to yield a helix angle versus transmural depth plot and HAT values. Both DT-CMR and histology were concordant in exhibiting the same trend of a significant decreased |HAT| in the placebo group compared with the CDCEXO-treated group. Furthermore, substantial correlation and agreement were found between histology and DT-CMR–derived |HAT| demonstrated in the correlation and Bland-Altman plot. DT-CMR = diffusion-tensor cardiac magnetic resonance. Abbreviation as in Figures 1 and 3.