Figure 7: GPVI-Fc*Fab2-XL Does Not Increase In Vitro Bleeding

Blood was either pre-incubated with no supplement, buffer, aspirin (ASA) (300 μg/ml), GPVI-Fc (333 nM), or GPVI-Fc*Fab2-XL (333 nM) before transfer to collagen/adenosine diphosphate (ADP) or collagen/epinephrine cartridges and determination of the in vitro closure time with the platelet function analyzer PFA-200. Mean ± SD; n = 6. ***p < 0.001 by repeated measures analysis of variance and secondary pair-wise comparison of ASA versus all other conditions. Abbreviations as in Figure 2.