Figure 7: Beneficial Effects of the Dual Action of Neurohumoral System in LCZ696 Treatment

Quantification of plasma (A) aldosterone and (B) cGMP levels by ELISA 3 days after MI. (C) The ratio of plasma aldosterone to plasma cGMP. n = 28 per group. In these box-and-whisker plots, lines within the boxes represent median values; the upper and lower lines of the boxes represent the 75th and 25th percentiles, respectively; and the upper and lower bars outside the boxes represent maximum and minimum values within 1.5 times the interquartile range from the 75th and 25th percentile, respectively. The inter-group comparisons were corrected by the Bonferroni’s multiple comparison test. cGMP = cyclic guanosine monophosphate; ELISA = enzyme-linked immunosorbent assay; other abbreviation as in Figure 1.