Figure 6: TERT Overexpression Prevents the Antiproliferative Effect of Everolimus on Neointima Formation

(A) Endothelial denudation injury was performed in femoral arteries of WT (n = 16) and TERTtg (n = 16) mice treated with vehicle or everolimus. Tissues were harvested 28 days after injury, and elastic Verhoeff-van Gieson staining was performed to visualize the internal and external elastic lamina. (B) Intima to media ratio was calculated as the intimal area divided by medial area. Data are presented as median and quartiles (significance level versus vehicle: ∗p = 0.046. Significance level versus WT: vehicle, #p = 0.048; Everolimus; #p = 0.034). Magnification × 100; scale bar = 50 μm. Abbreviations as in Figure 2.



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