Figure 5: Effects of JP2 Overexpression on Survival and Cardiac Function in CAPN1-OE Mice

(A) Kaplan-Meier survival curve for WT, CAPN1-OE, and CAPN1-OExJP2-OE mice (n = 32, 36, and 33, respectively). (B to D) Ejection fraction (B), ESV (C), and EDV (D) were assessed by echocardiography. (E, F) Average HW/BW (E) and LW/BW (F) ratios. n = 7 to 11 per group. *p < 0.05, **p < 0.01 versus age-matched WT; †p < 0.05 versus age-matched CAPN1-OE. CAPN1-OE = calpain-1 overexpressing; CAPN1-OExJP2-OE = calpain-1 overexpressing junctophilin-2 overexpressing double-transgenic cross; WT = wild-type; other abbreviations as in Figures 1, 2, and 4.