Figure 5: CM-Specific SMAD4 Deletion Leads to Cardiac Cell Death

(A) Representative images show terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL)–positive cardiomyocytes from the CTL and KO hearts. (B) Quantification shows significantly increased number of TUNEL-positive myocytes in KO mice at 8 weeks after TAM treatment. **p = 0.0069 versus CTL group. Scale bar = 30 μm. Abbreviations as in Figures 1, 2, and 3.



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