Figure 4: Rictor Deletion in Smooth Muscle Cells Causes Spontaneous Pulmonary Hypertension

RictorSM−/− mice spontaneously develop PH and imatinib reverses the established PH in RictorSM−/− mice. (A) Schematic strategy for the generation of RictorSM−/− mice and the timeline indicating the time for Tam injection (to induce Rictor KO) and experimental measurements. (B) Representative record of RVP (a) and summarized data (mean ± SE) showing the peak value of RVSP (b) (Kruskal-Wallis test, p < 0.001) and the Fulton index (RV/[LV + S]) ratio (c) (Kruskal-Wallis test, p = 0.001) in WT and RictorSM−/− mice 3 and 6 months after Tam injection with or without 2-week intraperitoneal injection of imatinib (20 mg/kg) daily. Dunn test, *p < 0.05, **p < 0.001, ***p < 0.001 versus WT; #p < 0.05, ##p < 0.01 versus RictorSM−/− (3 months). Summarized data of PA wall thickness in WT and RictorSM−/− mice 6 months after Tam injection (d). *p < 0.05 versus WT. The numbers of experiments or mice (n) for each group are indicated in each bar. Abbreviations as in Figure 1.



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