Figure 4: Renal Fibrosis and Plasma Creatinine Levels at 18 Weeks Post TAC

(A) Plasma creatinine levels. (B) Representative images (original magnification ×20) of Picrosirius red- stained renal tissue sections. (C) Quantified global renal fibrosis. (D) Relative fold changes in renal mRNA levels of fibrosis-related genes in mice from HF + Control, HF + JK-1 3 weeks post TAC, and HF + JK-1 10 weeks post TAC groups at 18 weeks post TAC. All data were analyzed with 1-way ANOVA. Circles inside bars denote the sample size. Abbreviations as in Figure 1.