Figure 4: Long-Term, High-Dose Treatment of 24-Week-Old

(A) Formation of formazan measured as change in absorbance in myocytes from untreated wt and mdx mice and PMO-treated mice (40 mg/kg PMO 3× per week for 19 weeks), after addition of 10 μM BayK(+) or BayK(–). (B) Mean ± SEM of increases in absorbance for all myocytes exposed to drugs as indicated. Dant = 20 μM dantrolene; Nisol = 15 μM nisoldipine; Oligo = 20 μM oligomycin; Ru360 = 15 μM; other abbreviations as in Figure 1.



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