Figure 4: Lipid-Containing Lesion Development Observed by OCT, NIRS, and Histology
2019-06-11T07:02:33Z (GMT) by
The development of an eccentric LL lesion was observed by OCT (A to C, arrowheads) and NIRS (D to F, yellow) from 9 (9M) to 12 (12M) and 15 (15M) months. The OCT cross-sections (A to C) correspond to the region in the NIRS chemograms (D to F), shown by the orange lines. At 15 months, a high lipid burden was detected by OCT (C, arrowheads) and NIRS (F, yellow). Histological analysis (G and H) of sequential sections stained with Oil red-O (G) and hematoxylin and eosin (H) stain confirmed the development of an eccentric atheromatous plaque with a large lipid pool (L in G1 and H1). The percentage of NIRS-positive segments increased over time in both FF-DM and FF-NDM swine (I). The graph shows the mean percentage of NIRS-positive segments per swine. Dist = distal; Prox = proximal; LCP = lipid core plaque; LL = lipid laden; other abbreviations as in Figure 1.