Figure 4: Efsevin Reduces Intracellular Ca

(A) Representative line scan confocal images from RyR2R4496C/WT cardiomyocytes show spontaneous Ca2+ sparks. (B) Treatment with ISO induced a higher spark frequency and amplitude and accelerated cytosolic Ca2+ removal (taudecay) leading to narrower (full width) and shorter (full duration) sparks. Administration of efsevin reduced Ca2+ spark frequency (p = 0.049, Kruskal Wallis test) and amplitude (p < 0.001, Kruskal Wallis test) and limited spatial (p < 0.001, Kruskal Wallis test) and temporal (p = 0.002, Kruskal Wallis test) expansion of Ca2+ sparks. *p < 0.05; **p < 0.01; ***p < 0.001. Abbreviations as in Figure 1.



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