Figure 4: Effects of Short-Term L-Phe on Aortic and Mesenteric Vascular Reactivity

Concentration response curves for acetylcholine in (A) WKY mesenteric rings, (B) SHR mesenteric rings, (C) WKY aortic rings, and (D) SHR aortic rings, with intact or denuded endothelium following short-term incubation with 0.5 mmol·l−1 L-phe. Data represent mean ± SEM n = 6 animals (in triplicate/animal) for mesenteric arteries and aortic rings (*p < 0.05 and *** p < 0.001 for the whole curve). Table (E) shows EC50 values (nmol·l−1) comparing saline control with L-phe treatment for each study. Data represent mean EC50 values ± SEM, n = 6 independent experiments (**p < 0.01 and ***p < 0.001). Ach = acetylcholine; EC50 = effective concentration for 50% maximal response; other abbreviations as in Figure 1.