Figure 4: Effect of ApoA-I Raising on Plasma Markers of Inflammation

At sacrifice, plasma MCP-1 and SAA were measured using enzyme-linked immunosorbent assay in the late-stage model receiving apoA-I raising by infusions (A and B) or lentiviral gene-transfer (C and D), and in the early-stage model receiving apoA-I infusions (E and F). Data are mean ± SD. Baseline n = 3 to 5, saline n = 15, apoA-I n = 15, LVGFP n = 8, LVApoA-I n = 8 mice/treatment for apoA-I infusions study and n = 6 to 8 mice/treatment for lentiviral gene transfer study. *p ≤ 0.05. MCP = monocyte chemoattractant protein; SAA = serum amyloid amylase; other abbreviations as in Figures 1 and 2.



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