Figure 4: Calcium Homeostasis Resists Pathological Remodeling in Ventricular Myocytes From Rad

(A) Representative whole-cell Fura-2 recordings for wild-type (WT) and Rad−/− myocytes isolated after sham or 14 weeks after left anterior descending coronary artery ligation. (B) Twitch calcium was significantly lowered in WT cells, as expected, but no change was observed in Rad−/− cells. (C) Fractional shortening was depressed in WT mice after myocardial infarction (MI) but not in Rad−/− mice. (D) Decay constant (tau) is slowed in WT mice by MI but preserved in Rad−/− mice. Data represent the averaged values for each mouse taken as the unit of analysis. N = 16 to 35 cells, n = 9 to 18 mice. *p < 0.05 versus WT sham; †p < 0.01 versus WT MI.