Figure 4: Brief Myocardial Ischemia Is Associated With a Transient Elevation in Cardiomyocyte Apoptosis

Example images of a TUNEL+ myocyte in the LAD-supplied region of the left ventricle 1 h after reperfusion are shown in the left panel (arrows). Tissue samples showed no pathological evidence of myocardial infarction. Compared with the nonischemic remote zone, there was a significant 6-fold increase in myocyte apoptosis in the ischemic LAD region 1 h after reperfusion. LAD apoptosis normalized 24 h later. †p < 0.05 versus remote. Abbreviations as in Figure 1.