Figure 3: Representative Images of LGE, CINE, HA Map, and |ΔHAT| p Value Wheel for Pre- and Post-CDC

For the CDCEXO subject, the red arrows point to a region of scar (anteroseptal) reduction in the LGE and a local restoration of the |HAT| with the endocardial fibers significantly (p < 0.05) changing from circumferential (HA ∼ 0) to right-handed helical (HA > 0) orientation (|HATpre| = 0.74°/%TD, |HATpost| = 0.95°/%TD). CINE revealed preserved LVEF. For the majority of the remote myocardium (anterolateral, inferolateral, inferior, and inferoseptal walls), |HAT| remained impaired with no significant change. For the placebo subject, LGE yielded no significant changes in scar size. CINE exhibited a reduction in LVEF. The |HAT| (white arrows) was significantly reduced in the inferoseptal wall with epicardial fibers changing from left-handed (HA < 0) to circumferential (HA ∼ 0) orientation (|HATpre| = 1.04°/%TD, |HATpost| = 0.78°/%TD). The |HAT| was also significantly reduced in the inferior wall with endocardial fibers changing from right-handed helical (HA > 0) to circumferential (HA ∼0) orientation (|HATpre| = 0.92°/%TD, |HATpost| = 0.69°/%TD). Anterolateral and inferolateral walls remained impaired with no significant change. CINE = cinematic magnetic resonance imaging; |HAT| = absolute helix angle transmurality; LGE = late gadolinium enhancement, TD = transmural depth; other abbreviation as in Figure 1.