Figure 3: Patients With or Without PDE5 Inhibitor Treatment

Hemodynamic changes during infusion of (Pyr1)apelin-13 (solid squares) or matched saline placebo (open squares) in patients with pulmonary arterial hypertension who are (A) on treatment with PDE5 inhibitors or (B) not on treatment with PDE5 inhibitors. Data are reported as mean ± SEM. *p = 0.049, **p = 0.0127, *** p = 0.0042, §p = 0.0039, §§p = 0.0017, #p = 0.0011, ##p = 0.0003, 2-way analysis of variance with post hoc Bonferroni tests. Abbreviations as in Figure 1.



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