Figure 3: Nox4 Modulates Cardiac Macrophage Polarization After I/R

(A to D) Flow cytometric quantification of total leukocytes, macrophages, and macrophage subsets according to Ly6c or MRC1 expression in the TG and WT left ventricle, 4 days’ post-MI. (E and F) Representative pseudocolor plots for macrophages based on Ly6c or MRC1 expression. (G and H) mRNA levels of the M2 markers MRC1 and CX3CR1 in whole left ventricle. (I and J) Ly6c- and MRC1+ macrophages as a proportion of total macrophages in the remote and ischemic areas of the left ventricle. n = 5 to 6 per group. #Significant interaction according to 2-way analysis of variance. Abbreviations as in Figures 1 and 2.



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