Figure 3: Monoclonal Antibodies to IL-17A or the IL-17RA Receptor Subunit, But Not IL-17F, Lowers Blood Pressure in Response to Ang II Infusion

Systolic blood pressure was measured at baseline and weekly during 28 days of Ang II infusion. Arrows indicate timing of antibody administration. Data are expressed as mean ± SEM and were analyzed at day 28 using 1-way analysis of variance followed by Holm-Sidak post hoc test (n = 7 to 20 per group). ***p < 0.001 vs. mouse IgG1. Ab = antibody; other abbreviations as in Figures 1 and 2.