Figure 3: Krebs (TCA) Cycle Intermediates

The center diagram depicts the TCA cycle following pyruvate oxidation, and the graphs show the quantitative comparisons of TCA intermediates in cardiac tissue of NDs and at the pre- and post-LVAD time points. Despite the post-LVAD increase of pyruvate, early TCA cycle intermediates, that is, citrate and α-ketoglutarate, remained unaltered in the post-LVAD unloaded human heart, whereas levels of succinate, fumarate and malate are increased. Abbreviations as in Figure 2.