Figure 3: Effects of CDCs on Mortality and Heart Failure

Cardiosphere-derived cell (CDC) treatment improves survival (A; X axis shows days from treatment, or equivalent age in control rats) and pulmonary congestion (B) (lung weight [left] and lung weight/body weight [right]) in rats with heart failure with preserved ejection fraction (HFpEF). (C) At endpoint, body weight loss induced by HFpEF is partially restored by CDC treatment (n = 10 for control rats, n = 15 for placebo-treated rats, and n = 18 for CDC-treated rats). Log-rank for CDCs versus placebo. *p < 0.05 versus placebo- and CDC-treated rats, †p < 0.05 versus control and CDC-treated rats, and ‡p < 0.05 versus placebo-treated rats, all by analysis of variance. ttt = treatment.