Figure 3: Effects of ATP Versus dATP

Effects of ATP versus dATP in ex vivo human cardiac tissue from end-stage HF patients demonstrating dATP increases force. (A) Representative isometric force trace of demembranated tissue at pCa 5.6 with ATP or dATP. (B) Force measured at pCa 5.6 with 10%, 25%, 50%, and 100% dATP compared with 100% ATP (n = 4 at each dATP concentration). Measurements are mean ± SEM. *p < 0.05 compared with 100% ATP by paired Student t test.