Figure 3: Clinical Neurologic Outcomes

(A) Hydrogen-treated swine exhibited significantly higher rates of neurologically intact survival, which was defined as an SNDS ≤120 at the time of death (log-rank test: p = 0.0035). The overall rates of survival were similar between groups (log-rank test: p = 0.1435). (B) Hydrogen-treated swine exhibited significantly lower SNDS at 1, 2, and 3 days post injury (2-way ANOVA: p < 0.0001). Data for day 1 represent 8 swine per group; data for days 2 and 3 represent 8 swine in the hydrogen group and 6 in the control group (2 swine allocated to the control group died from refractory seizures and could not be successfully extubated). ***p < 0.001; **p < 0.01 for daily differences according to Sidak’s multiple comparisons post test. ANOVA = analysis of variance; DHCA = deep hypothermic circulatory arrest; SNDS = Swine Neurodevelopment Score.