Figure 3: ApoA-I Reduces Circulating Activated Monocytes After PCI

Donor thoracic aortas from apoE−/− were subjected to balloon angioplasty and then carotid interposition grafted into recipient apoE−/− mice. Recipient mice received systemic infusions of PBS or apoA-I (40 mg/kg) on alternate days 1 week before surgery and until euthanasia 28 days post-surgery (n = 8/treatment group). One, 2, and 4 weeks post-surgery, circulating (A) CD45hiCD115loLy6-C/Ghi neutrophils, (B) CD45hiCD115hi monocytes, and (C) Ly6-C/Ghi activated monocytes were measured by flow cytometry. Data are expressed as mean ± SD. Abbreviations as in Figures 1 and 2.