Figure 2: The Physiological Consequences of Agonism, Antagonism, and Biased Agonism of the AT

This is a cartoon representation outlining the effect on cardiovascular signaling and outcomes when the AT1R is differentially affected by direct agonism or antagonism versus the potential beneficial effect of β-arrestin–targeted biased agonism. Ca2+ = calcium ion; other abbreviations as in Figure 1.