Figure 2: MDL-28170 Protects Against Cardiac Stress–Induced Heart Failure

(A) Calpain activity was assessed in LV lysates after TAB, MI, or ISO minipump infusion. (B and C) Average heart weight/body weight (B) and lung weight/body weight (C) ratios at 5 weeks after surgery or 2 weeks after ISO minipump implantation. (D to F) End-systolic volume (ESV) (D), end-diastolic volume (EDV) (E), and ejection fraction (EF) (F) were assessed by echocardiography. n = 7 to 11 mice per group. For A, **p < 0.01 as indicated. For B to F, *p < 0.05, **p < 0.01 versus sham; †p < 0.05, ††p < 0.01 versus saline control. Control = the saline control beginning 3 days after surgery; HW/BW = heart weight/body weight; ISO = isoproterenol; LV = left ventricular; LW/BW = lung weight/body weight; MDL = MDL-28170 beginning 3 days after surgery; MI = myocardial infarction; Sham = sham surgery; TAB = transverse aortic banding.