Figure 2: LRP1 Expression Is Increased in Heart During Acute Myocardial Infarction

(A) Low-density lipoprotein receptor–related protein-1 (LRP1) expression is significantly increased in the heart of patients with end-stage heart failure due to prior myocardial infarction undergoing heart transplantation, compared with subjects who died of noncardiac causes (p < 0.001; n = 6 per group). (B) Increased LRP1 expression is seen in the heart of mice subject to myocardial ischemia (30 min) and reperfusion (24 h) (top right panel) (p = 0.003, n = 4 per group). The immunofluorescence for LRP1 (red) and cardiac muscle actin (green) showing (C) increased LRP1 expression in areas bordering the infarct zone, (D) compared with sham-operated mice. GAPDH = glyceraldehyde 3-phosphate dehydrogenase.