Figure 2: Glycolytic Metabolites in the Nonfailing Donor Heart and the Failing Heart Before and After LVAD Unloading

The diagram depicts glycolytic metabolism of glucose derived from glycogen or extracellular glucose. Glycolytic intermediates are increased following left ventricular assist device (LVAD) unloading as exemplified by glucose 1 phosphate, glucose 6 phosphate, pyruvate, and also increased levels of lactate. CoA = coenzyme A; ND = nonfailing donor heart; TCA = tricarboxylic acid.