Figure 2: Effects of Short-Term and Long-Term L-Phe on Tissue BH

Short-term (100 mg·kg−1 L-phe, oral gavage, 4 h, n = 6) and long-term administration (2.5% L-phe in drinking water for 60 days, n = 6) in SHR on (A) BH4, (B) nitrite, (C) BH2, and (D) biopterin in heart, lung, and liver tissues. The datasets shown represent the mean ± SEM where *p < 0.05, **p < 0.01, and ***p < 0.001. (Exact p values are in the Supplemental Data.) Abbreviations as in Figure 1.