Figure 2: Cellular Responses to Injected Biomaterials

2019-06-11T07:04:11Z (GMT) by Melissa J. Hernandez Karen L. Christman
Upon injection of a biomaterial, the resulting cellular responses can largely affect eventual tissue regeneration. Hematoxylin and eosin images are shown for (A) a decellularized myocardial extracellular matrix hydrogel (3 days post-injection), (B) acetalated dextran microparticles (7 days post-injection), (C) a methacrylated hyaluronic acid hydrogel (1 day post-injection), (D) a poly(N-isopropylacrylamide)-based synthetic hydrogel (8 weeks post-injection), and (E) an alginate hydrogel (14 days post-injection). (F) Masson’s trichrome staining shows residual alginate in a heart section 5 weeks post-injection. All tissue sections are from the heart except for (E), which is skeletal muscle. Black arrows, asterisks, and “G” denote the biomaterial.