Figure 1: Ticagrelor Reduces Ex Vivo ADP-Induced Platelet Aggregation in Pneumonia Patients

Maximum platelet aggregation was measured by light transmission aggregometry in PRP in response to 5 μmol/l ADP (A) and 15 μmol/l TRAP (C). Area under the curve values in the Multiplate assay are shown with ADP (B) or TRAP (D) as an agonist. Patients randomized to placebo are represented by open circles and patients randomized to ticagrelor are represented by filled circles. A significant difference between groups on the change from baseline to 24 h is indicated by an asterisk. ADP = adenosine diphosphate; AU = arbitrary units; BL = baseline; LTA = light transmission aggregometry; TRAP = thrombin receptor activating peptide



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