Figure 1: Mortality Is Reduced in Rad

(A) Survival curve of wild-type (WT) and Rad−/− shows significantly fewer spontaneous deaths in Rad−/− mice. *p < 0.05, WT versus Rad−/− mice. N = 63 WT myocardial infarction (MI), 75 Rad−/− MI, 25 WT sham, and 33 Rad−/− sham mice at risk at day 0. After 50 days, there were 58 WT MI mice at risk, and at 100 days, there were 57 WT MI mice at risk; all other counts remained the same as at 0 days. (B) Long-axis echocardiographic images taken during diastole. Arrows denote boundaries of scar region. (C) Representative hearts fixed after 5 weeks of ischemia. Arrow indicates suture occluding the left anterior descending coronary artery. (D) Representative sections of post-MI hearts stained for Masson’s trichrome. Arrows mark interstitial fibrosis. (E) Measurements of scar length in post-MI WT and Rad−/− hearts as a percentage of the left ventricular midline. (F) Interstitial fibrosis score in noninfarcted myocardium (1 = little to no fibrosis, 5 = severe fibrosis). N = 5 WT and 11 Rad−/− mice.