Figure 1: DSMB Reviews and Recommendations in TOPCAT

The Data and Safety Monitoring Board’s (DSMB) timeline, reviews, and recommendations (A) From December 2006 to October 1, 2010, and (B) October 27, 2010 to September 2013 for the TOPCAT (Treatment of Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist Trial). BNP = B-type natriuretic peptide; CAD = coronary artery disease; CRA = Clinical Research Associate; CTCC = Clinical Trial Coordinating Center; HF = heart failure; HFpEF = heart failure with preserved ejection fraction; NI = myocardial infarction; NA = North America; NHLBI = National Heart, Lung, and Blood Institute; NL = normal limits; NP = natriuretic peptide; NT-proBNP = N-terminal pro–B-type natriuretic peptide; SC = Steering Committee; Sx = symptoms; WNL = within normal limits.