Figure 1: ApoA-I Reduces Neointimal Area Following Stent Deployment

Stents were deployed into the thoracic aorta of donor apoE−/− mice. Stented aortas were then carotid interposition grafted into recipient apoE−/− mice. Recipient mice received systemic infusions of PBS or apoA-I (40 mg/kg) on alternate days 1 week before surgery and until euthanasia 28 days post-surgery (n = 8 to 10/treatment group). Resin-embedded transverse sections of stented vessels were stained with hematoxylin and eosin, and assessed for changes in (A) total neointimal area and (B) strut to lumen distance. Black arrows indicate an example of the distance measured for the strut-to-lumen measurement. Data are expressed as mean ± SD. apoA-I = apolipoprotein A-I; PBS = phosphate-buffered saline.