Central Illustration: GRKs Demonstrate Isoform-Specific Functions in the Regulation of Cardiac Signaling and Function

AR = adrenergic receptor; ARKct = adrenergic receptor kinase carboxy-terminal peptide; AT1R = angiotensin II type 1A receptor; beta = beta subunit; G alpha q = G alpha q subunit; gamma = gamma subunit; GRK = G protein--coupled receptor kinase; GRK3ct = G protein–coupled receptor kinase 3 carboxy-terminal peptide; OE = over-expression.