Central Illustration: Extracellular Vesicles as Regulators of Vascular Health and Disease

Many types of cells release EVs, such as exosomes and microvesicles, by different mechanisms. EVs have both favorable and detrimental effects on vascular integrity. The use of genetically modified EVs might represent a novel therapeutic tool in the field of cardiovascular medicine and regenerative therapy. EV = extracellular vesicles; miRNA = microRNA.