Visual Abstract - The Role of the L-Type Ca2+ Channel in Altered Metabolic Activity in a Murine Model of Hypertrophic Cardiomyopathy: 10.1016/j.jacbts.2015.12.001
Heterozygous mice (αMHC403/+) expressing the human hypertrophic cardiomyopathy (HCM) disease causing mutation Arg403Gln exhibit cardinal features of HCM.
This study investigated the role of L-type Ca2+ channel (ICa-L) in regulating mitochondrial function in Arg403Gln (αMHC403/+) mice.
Activation of ICa-L in αMHC403/+mice caused a significantly greater increase in mitochondrial membrane potential and metabolic activity when compared to wild-type mice.
Increases in mitochondrial membrane potential and metabolic activity were attenuated with ICa-L antagonists and when F-actin or β-tubulin were depolymerized.
ICa-L antagonists may be effective in reducing the cardiomyopathy in HCM by altering metabolic activity.