Visual Abstract - Phosphorylation of Hsp20 Promotes Fibrotic Remodeling and Heart Failure: 10.1016/j.jacbts.2018.11.007

• PKA-phosphorylation of Hsp20 is elevated in human failing hearts.

• Increases in phosphorylated Hsp20 in vivo are associated with fibrotic remodeling and reduced left ventricular function.

• The phosphorylated Hsp20 in cardiomyocyte promotes upregulation of IL-6 and its subsequent paracrine actions on the cardiac fibroblast.

• Blockade of IL-6 effects ex vivo and in vivo reduces the pro-fibrotic effects of phosphorylated Hsp20.

• Targeting phosphorylated Hsp20 in the cardiomyocyte may represent a potential therapeutic strategy to mitigate fibrotic remodeling and preserve function in the failing heart.

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