Visual Abstract - Phosphorylation of Hsp20 Promotes Fibrotic Remodeling and Heart Failure: 10.1016/j.jacbts.2018.11.007
2019-06-13T11:02:24Z (GMT)
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• PKA-phosphorylation of Hsp20 is elevated in human failing hearts.
• Increases in phosphorylated Hsp20 in vivo are associated with fibrotic remodeling and reduced left ventricular function.
• The phosphorylated Hsp20 in cardiomyocyte promotes upregulation of IL-6 and its subsequent paracrine actions on the cardiac fibroblast.
• Blockade of IL-6 effects ex vivo and in vivo reduces the pro-fibrotic effects of phosphorylated Hsp20.
• Targeting phosphorylated Hsp20 in the cardiomyocyte may represent a potential therapeutic strategy to mitigate fibrotic remodeling and preserve function in the failing heart.
