Visual Abstract - Glucagon Receptor Antagonism Ameliorates Progression of Heart Failure: 10.1016/j.jacbts.2018.11.001

• Systemic treatment of an antibody-based glucagon receptor antagonist confers cardioprotection against myocardial infarction and post-myocardial infarction remodeling in mice.

• Systemic treatment of glucagon receptor antagonist prevents pressure overload induced cardiac remodeling and dysfunction in mice.

• Glucagon receptor antagonist treatment attenuates the pathological progression of heart failure induced by pressure overload in mice.

• Long-term suppression of glucagon signaling is potentially an effective therapy for heart failure with different etiologies independent of metabolic disorders.