Visual Abstract - Elamipretide Improves Mitochondrial Function in the Failing Human Heart: 10.1016/j.jacbts.2018.12.005

• Mitochondrial function is impaired in explanted failing pediatric and adult human hearts.

• Elamipretide is a novel mitochondria-targeted drug that is targeted to cardiolipin on the inner mitochondrial membrane and improves coupling of the electron transport chain.

• Treatment of explanted human hearts with elamipretide improves human cardiac mitochondrial function.

• The study provides novel methods to evaluate the influence of compounds on mitochondria in the human heart and provides proof of principle for the use of elamipretide to improve mitochondrial energetics in failing myocardium due to multiple etiologies and irrespective of age.