Visual Abstract - Deletion of Sulfonylurea Receptor 2 in the Adult Myocardium Enhances Cardiac Glucose Uptake and Is Cardioprotective: 10.1016/j.jacbts.2018.11.012

• In the heart, SUR2 couples with a potassium channel to form an adenosine triphosphate–sensitive complex that responds to the energy state of the cell.

• The authors deleted SUR2 in adult cardiomyocytes and found a shift of the heart toward glycolytic metabolism, which is protective under cardiac stress.

• SUR2 was found to complex with glucose transporter type 4, the major glucose transporter.

• Drugs that antagonize the SUR2 receptor may be cardioprotective and useful for managing heart failure.