Visual Abstract - Celecoxib Is Associated With Dystrophic Calcification and Aortic Valve Stenosis: 10.1016/j.jacbts.2018.12.003

• Celecoxib use is associated with diagnosis of aortic stenosis in analysis of electronic medical records.

• Celecoxib treatment increases dystrophic calcification of aortic valve interstitial cells in vitro.

• Dimethyl celecoxib, which binds CDH11, prevents TGF-β1–mediated calcification of aortic valve interstitial cells in vitro.