Figure 9: PP2Ce Expression Impairs Function Recovery Following Ischemia/Reperfusion Injury

(A) Left ventricle dP/dt max during 15-min global ischemia followed by 60-min reperfusion in isolated hearts from nontransgenic control subjects (control, n = 9) and PP2Ce TG (TG, n = 6) mice. Left ventricle function parameters measured as (B) left ventricular developed pressure (LVDP), (C) systolic pressure increase (dP/dt max), (D) diastolic pressure decrease (dP/dt min), and (E) relaxation time index (Tau) in nontransgenic control subjects (control, n = 9) and PP2Ce TG hearts (n = 6) at basal and 45 min after reperfusion. **p < 0.01 between control and PP2Ce TG groups. #p < 0.05; ##p < 0.01 between corresponding control and PP2Ce TG groups at each time point.

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