Figure 8: Transcriptomic Analysis Reveals Profound CDC-Responsive Changes of Gene Expression in HFpEF

(A) Heat map showing the transcripts that are up- or downregulated by heart failure with preserved ejection fraction (HFpEF) and normalized partially or completely by cardiosphere-derived cell (CDC) treatment. (B) Selected genes involved in inflammation and fibrosis or associated with HFpEF that are rescued by CDC treatment (abbreviations in Supplemental Table 1). (C) Selected pathways modified by CDC treatment compared with placebo; blue, inhibited; orange, activated; white, not clear from the database (published research missing).