Figure 8: Schematic Diagram of the Proposed Model of the Mechanism of the Protective Effect of LCZ696 Against Post-MI Cardiac Rupture

Proposed model of the mechanism that LCZ696 (sacubitril/valsartan), which simultaneously regulate RAAS and NPS, can protect against cardiac rupture after MI through the suppression of pro-inflammatory cytokines and ECM degradation. ECM = extracellular matrix; NPS = natriuretic peptide system; RAAS = renin-angiotensin-aldosterone system; other abbreviations as in Figures 1 and 4.